About us
Global DDI Solutions was founded in 2022 by Prof. Dr. David Burger and Ms. Alice Posthumus-Plantinga to develop a suite of industry-leading drug-drug interactions (DDIs) tools and educational programs to support better quality prescribing and optimize quality of life for patients.
Global DDI Solutions aims at recording the interactions of drugs treating various diseases, and for that purpose, several DDI tools are being set up based on a central DDI database.
These tools can be accessed via disease-specific DDI websites and can be used to enable quick screening of drug interactions.
Resources
The user-friendly interface of our online DDI Managers ® allows you to access a pharmacological database of potential drug-drug interactions, alerting you to possible interactions and protecting your patients from adverse drug-drug events. The tools facilitate targeted interaction checks and include tailored advice on managing these interactions. All disease-specific DDI tools are developed in partnership with Radboud University Medical Center Nijmegen.
COVID-19 DDI Checker Platform
The COVID-19 Interactions Interface is a comprehensive DDI tool for medical health professionals. This tool provides a user-friendly pharmacological database of potential drug-drug interactions with Nirmatrelvir + Ritonavir (Paxlovid®). Nirmatrelvir + Ritonavir is an antiviral medicine that works by stopping the virus that causes coronavirus (COVID-19) from growing and spreading in the body. While research with Nirmatrelvir+Ritonavir has shown it to reduce hospital admissions and/or mortality in high-risk groups, it is known to have several drug-drug interactions.
The COVID-19 DDI Checker Platform is now available for the Netherlands (in Dutch) and Zambia (in English).
DDI Manager® Lung Cancer
Patients with lung cancer have an increased risk for the development of drug-drug interactions (DDIs) due to increased comorbidities and the risk of polypharmacy. There is a growing body of evidence to show that DDIs in these patients have significant clinical consequences.
To counteract this risk, we proudly present our new specialized Lung Cancer DDI Manager – a cutting-edge tool developed by GDDIS in partnership with leading experts in the field, launched in November 2023.
This comprehensive, up-to-date resource provides you with accurate, independent data on pharmacokinetics and therapeutic monitoring of drugs used to treat lung cancer.
https://ddimanager.co/search/lung-cancer
DDI Manager® Prostate Cancer
We are delighted to announce that the new Prostate Cancer DDI Manager has been added to our suite of leading DDI tools. This comprehensive up-to-date resource contains DDI Management recommendations for 9 prostate cancer agents and approximately 1,000 co-medications. Prostate cancer predominantly affects older men, who often have multiple comorbidities, with polypharmacy being common.
Several prostate cancer agents can be a ‘perpetrator’ or ‘victim’ of DDIs due to inducing CYP450 enzymes and/or membrane transporters. Acid-reducing agents can influence the pH-dependent absorption of prostate cancer agents, especially abiraterone. Adding treatment for prostate cancer to existing polypharmacy increases the risk of drug-drug interactions (DDIs).
To counteract these risks, the Prostate Cancer DDI Manager was conceived and developed in partnership with leading experts in the field.
https://ddimanager.co/search/prostate-cancer
DDI Manager® Fungal Infections
Patients who develop invasive fungal infections are often immunocompromised, with polypharmacy being common. With this polypharmacy comes an increased risk of drug-drug interactions. To counteract this risk, we proudly announce our Antifungal DDI Manager.
This comprehensive, up-to-date resource will provide accurate, independent data on antifungal pharmacokinetics and therapeutic drug monitoring.
https://ddimanager.co/search/antifungal
DDI Manager® CMV
Patients diagnosed with cytomegalovirus often have multiple comorbidities and are immunosuppressed, with polypharmacy being common. Adding CMV treatment to already existing polypharmacy increases the risk of drug-drug interactions (DDIs).
To counteract this risk – our new CMV DDI Manager! Launched in April 2024, this comprehensive, up-to-date resource will provide accurate, independent data on 7 separate drugs related to CMV pharmacokinetics and therapeutic drug monitoring.
This website has been made possible through sponsorship by Pfizer BV. Pfizer BV has no influence on the content, advice, or development of this website.
Analyze prescription and over-the-counter product drug interactions to determine what drug combinations your patients may encounter.
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